About Ocifisertib(CFI-400945 free base)
PKA phosphorylates Myosin Binding Protein-C (MyBP-C) and troponin I (TnI) within the cardiac myofibril. TnI may be the inhibitory element of the trimeric troponin molecule that makes up the Ca2+-switch of the contractile equipment. TnI binds to TnC when Ca2+ is certain to TnC, while inside the absence of Ca2+, the C-terminus of TnI is unveiled and